Dr. Richard Frye (often referred to as Dr. Frye) has conducted and contributed to several research studies on leucovorin (also known as folinic acid or leucovorin calcium), primarily in the context of autism spectrum disorder (ASD), folate metabolism abnormalities, and cerebral folate deficiency. His work often focuses on how leucovorin may improve symptoms like verbal communication in certain subgroups of children with ASD.

Here are key links to his prominent research studies and related publications (primarily from PubMed and ClinicalTrials.gov, where most peer-reviewed papers and trials are hosted):

1. Treatment of Folate Metabolism Abnormalities in Autism Spectrum Disorder (2020 review by Frye et al.) – https://pubmed.ncbi.nlm.nih.gov/32892962/
2. Cerebral Folate Deficiency, Folate Receptor Alpha Autoantibodies and Leucovorin (Folinic Acid) Treatment in Autism Spectrum Disorders: A Systematic Review and Meta-Analysis (2021, with Rossignol and Frye) – https://pubmed.ncbi.nlm.nih.gov/34834493/
3. Binding Folate Receptor Alpha Autoantibody Is a Biomarker for Leucovorin Treatment Response in Autism Spectrum Disorder (2024 by Frye et al.) – https://pubmed.ncbi.nlm.nih.gov/38248763/
4. The Soluble Folate Receptor in Autism Spectrum Disorder: Relation to Autism Severity and Leucovorin Treatment (2022 by Frye et al.) – https://pubmed.ncbi.nlm.nih.gov/36556254/
5. Clinical trial: Leucovorin for the Treatment of Language Impairment in Children With Autism Spectrum Disorder (NCT02839915, led by Frye) – https://clinicaltrials.gov/study/NCT02839915
6. Clinical trial: Early Treatment of Language Impairment in Young Children With Autism Spectrum Disorder With Leucovorin Calcium (NCT04060017, led by Frye) – https://clinicaltrials.gov/study/NCT04060017

For more of his related work, you can check his profile or research articles page, which lists additional papers – https://drfryemdphd.com/research

Note that while some studies show promising results for symptom improvement (especially verbal communication), the evidence comes from smaller trials and reviews, and larger studies are often mentioned as needed for confirmation. Always consult a healthcare professional for personalized advice.